Mitchell D. Knutson, Ph.D.


  • Jenkitkasemwong S, Wang C, Coffey R, Zhang W, Chan A, Biel T, Kim J, Hojyo S, Fukada T, Knutson MD. SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis. Cell Metabolism. 2015 May 28. [Jenkitkasemwong et al Cell Metabolism 2015 PDF]
  • Tripathi AK, Haldar S, Qian J, Beserra A, Suda S, Singh A, Hopfer U, Chen SG, Garrick MD, Turner JR, Knutson MD, Singh N. Prion protein functions as a ferrireductase partner for ZIP14 and DMT1. Free Radic Biol Med. 2015 Apr 8;84:322-330. doi: 10.1016/j.freeradbiomed.2015.03.037. [PubMed][Tripathi et al. PDF]
  • Zhao N, Zhang AS, Worthen C, Knutson MD, and Enns CA. An iron-regulated and glycosylation-dependent proteasomal degradation pathway for the plasma membrane metal transporter ZIP14. Proc Natl Acad Sci U S A. 2014 Jun 9. [PubMed][PNAS-2014-Zhao-PDF]
  • Coffey R, Nam H, and Knutson MD. Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload. PLoS One. January 21, 2014. [PubMed][Coffey et al., PLoS One.2014]
  • Guo X, Zhang Z, Zhang F, Tao Y, An P, Wu Q, Wang CY, Knutson MD, Wang F. Fine-Mapping and Genetic Analysis of the Loci Affecting Hepatic Iron Overload in Mice. PLoS One. 2013 May 10. [PubMed][2013. Guo et al. Plos One-PDF]
  • Wang CY and Knutson MD. Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice. Hepatology. 2013;58(2):788-98. [PubMed][Wang and Knutson.Hepatology.2013]
  • Nam H, Wang CY, Zhang L, Zhang W, Hojyo S, Fukada T, and Knutson M.
    ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by
    iron deficiency and overload: implications for tissue iron uptake in iron-related disorders. Haematologica. 2013; 98(7):1049-57 [PubMed][Nam et al.Haematologica.2013]
  • Wang CY, Jenkitkasemwong S, Duarte S, Sparkman B, Shawki A, Mackenzie B,Knutson MD. ZIP8 is an iron and zinc transporter whose cell-surface expression is upregulated by cellular iron loading. J Biol Chem. 2012; 287(41); 34032-34043.
    Aug 16. [PubMed][2012.Wang et al.JBC - PDF]
  • Xu J, Jia Z, Knutson MD, Leeuwenburgh C. Impaired iron status in aging research. Int J Mol Sci. 2012;13(2):2368-2386. [PubMed][2012.Xu et al. IJMS - PDF]
  • Xu J, Hwang JC, Lees HA, Wohlgemuth SE, Knutson MD, Judge AR, Dupont-Versteegden EE, Marzetti E, Leeuwenburgh C. Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy. Exp Gerontol. 2012;47(1):100-108. [PubMed][2012.Xu et al. ExperGerontol - PDF]
  • Zhang Z, Zhang F, An P, Guo X, Shen Y, Tao Y, Wu Q, Zhang Y, Yu Y, Ning B, Nie G, Knutson MD, Anderson GJ, Wang F. Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses. Blood. 2011;118(7):1912-1922. [PubMed][2011.Zhang et al.Blood - PDF]
  • Pinilla-Tenas JJ, Sparkman BK, Shawki A, Illing AC, Mitchell CJ, Zhao N, Liuzzi JP, Cousins RJ, Knutson MD, Mackenzie B. Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. Am J Physiol Cell Physiol. 2011;301(4):C862-871. [PubMed][2011.Pinilla-Tenas et al. AJP - PDF]
  • Zhao N, Gao J, Enns CA, Knutson MD. ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin. J Biol Chem. 2010;285(42):32141-32150. [PubMed][2010.Zhao et al.JBC - PDF]
  • Jenkitkasemwong S, Broderius M, Nam H, Prohaska JR, Knutson MD. Anemic copper-deficient rats, but not mice, display low hepcidin expression and high ferroportin levels. J Nutr. 2010;140(4):723-730. [PubMed][2010.Jenkitkasemwong et al..J Nutr - PDF]
  • Hansen SL, Ashwell MS, Moeser AJ, Fry RS, Knutson MD, Spears JW. High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves. J Dairy Sci. 2010;93(2):656-665. [PubMed][2010.Hansen et al. J Dairy Sci - PDF]
  • Koeppen AH, Morral JA, Davis AN, Qian J, Petrocine SV, Knutson MD, Gibson WM, Cusack MJ, Li D. The dorsal root ganglion in Friedreich’s ataxia. Acta Neuropathol. 2009;118(6):763-776. [PubMed][2009.Koeppen et al.ActaNeuorpathol - PDF]
  • Knutson MD. Into the matrix: regulation of the iron regulatory hormone hepcidin by matriptase-2. Nutr Rev. 2009;67(5):284-288. [PubMed][2009.Knutson.Nutr Rev - PDF]
  • Hepburn JJ, Arthington JD, Hansen SL, Spears JW, Knutson MD. Technical note: copper chaperone for copper, zinc superoxide dismutase: a potential biomarker for copper status in cattle. J Anim Sci. 2009;87(12):4161-4166. [PubMed][2009.Hepburn et al. J Anim Sci - PDF]
  • Genter MB, Kendig EL, Knutson MD. Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level? Ann N Y Acad Sci. 2009;1170:623-628. [PubMed][2009.Genter.Ann NY Acad Sci - PDF]
  • Aydemir F, Jenkitkasemwong S, Gulec S, Knutson MD. Iron loading increases ferroportin heterogeneous nuclear RNA and mRNA levels in murine J774 macrophages. J Nutr. 2009;139(3):434-438. [PubMed][2009.Aydemir et al., J Nutr - PDF]
  • Andriopoulos B, Jr., Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietrangelo A, Vukicevic S, Lin HY, Babitt JL. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009;41(4):482-487. [PubMed][2009.Andriopoulos B et al.NatGenet - PDF]
  • Xu J, Knutson MD, Carter CS, Leeuwenburgh C. Iron accumulation with age, oxidative stress and functional decline. PLoS One. 2008;3(8):e2865. [PubMed][2008.Xu et al. PLoSONE - PDF]
  • Seo AY, Xu J, Servais S, Hofer T, Marzetti E, Wohlgemuth SE, Knutson MD, Chung HY, Leeuwenburgh C. Mitochondrial iron accumulation with age and functional consequences. Aging Cell. 2008;7(5):706-716. [PubMed][2008.Seo et al.AgingCell. - PDF]
  • King SM, Donangelo CM, Knutson MD, Walter PB, Ames BN, Viteri FE, King JC. Daily supplementation with iron increases lipid peroxidation in young women with low iron stores. Exp Biol Med (Maywood). 2008;233(6):701-707. [PubMed][2008.King et al. Exp Biol Med - PDF]
  • Hofer T, Marzetti E, Xu J, Seo AY, Gulec S, Knutson MD, Leeuwenburgh C, Dupont-Versteegden EE. Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy. Exp Gerontol. 2008;43(6):563-570. [PubMed][2008.Hofer et al.Exp Gerontol. - PDF]
  • Gao J, Zhao N, Knutson MD, Enns CA. The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. J Biol Chem. 2008;283(31):21462-21468. [PubMed][2008.Gao et al., JBC - PDF]
  • Koeppen AH, Michael SC, Knutson MD, Haile DJ, Qian J, Levi S, Santambrogio P, Garrick MD, Lamarche JB. The dentate nucleus in Friedreich’s ataxia: the role of iron-responsive proteins. Acta Neuropathol. 2007;114(2):163-173. [PubMed][2007.Koeppen et al.ActaNeuropathol - PDF]
  • Imrich A, Ning Y, Lawrence J, Coull B, Gitin E, Knutson M, Kobzik L. Alveolar macrophage cytokine response to air pollution particles: oxidant mechanisms. Toxicol Appl Pharmacol. 2007;218(3):256-264. [PubMed][2007.Imrich A et al. Toxicol Appl Pharm - PDF]
  • Michael S, Petrocine SV, Qian J, Lamarche JB, Knutson MD, Garrick MD, Koeppen AH. Iron and iron-responsive proteins in the cardiomyopathy of Friedreich’s ataxia. Cerebellum. 2006;5(4):257-267. [PubMed][2006.Michael et al. Cerebellum - PDF]
  • Liuzzi JP, Aydemir F, Nam H, Knutson MD, Cousins RJ. Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci U S A. 2006;103(37):13612-13617. [PubMed][2006.Liuzzi et al.PNAS - PDF]
  • Chlosta S, Fishman DS, Harrington L, Johnson EE, Knutson MD, Wessling-Resnick M, Cherayil BJ. The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica. Infect Immun. 2006;74(5):3065-3067. [PubMed][2006.Chlosta et al.InfectImmun - PDF]
  • Brain JD, Heilig E, Donaghey TC, Knutson MD, Wessling-Resnick M, Molina RM. Effects of iron status on transpulmonary transport and tissue distribution of Mn and Fe. Am J Respir Cell Mol Biol. 2006;34(3):330-337. [PubMed][2006.Brain et al.Am J Respir Cell Mol Biol - PDF]
  • Liuzzi JP, Lichten LA, Rivera S, Blanchard RK, Aydemir TB, Knutson MD, Ganz T, Cousins RJ. Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A. 2005;102(19):6843-6848. [PubMed][2005.Liuzzi et al.PNAS - PDF]
  • Knutson MD, Oukka M, Koss LM, Aydemir F, Wessling-Resnick M. Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc Natl Acad Sci U S A. 2005;102(5):1324-1328. [PubMed][2005.Knutson et al.J Nutr - PDF]
  • Knutson MD, Vafa MR, Haile DJ, Wessling-Resnick M. Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages. Blood. 2003;102(12):4191-4197. [PubMed][2003.Knutson et al.,Blood - PDF]
  • Walter PB, Knutson MD, Paler-Martinez A, Lee S, Xu Y, Viteri FE, Ames BN. Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc Natl Acad Sci U S A. 2002;99(4):2264-2269. [PubMed][2002.Walter et al. PNAS - PDF]
  • Knutson MD, Levy JE, Andrews NC, Wessling-Resnick M. Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice. J Nutr. 2001;131(5):1459-1464. [PubMed][2001.Knutson et al. J Nutr - PDF]
  • Knutson MD, Walter PB, Ames BN, Viteri FE. Both iron deficiency and daily iron supplements increase lipid peroxidation in rats. J Nutr. 2000;130(3):621-628. [PubMed][2000.Knutson et al.J Nutr - PDF]
  • Knutson MD, Viteri FE. Concentrating breath samples using liquid nitrogen: a reliable method for the simultaneous determination of ethane and pentane. Anal Biochem. 1996;242(1):129-135. [PubMed][1996.Knutson & Viteri.Anal Biochem - PDF]



EWIC 2014

East-to-West Iron Club (EWIC)

October 16-17, 2014 – Saint Louis, MO

img_slu2The East-to-West Iron Club (EWIC) is an annual meeting for researchers interested in iron metabolism. The centerpiece of the meeting – held annually since 1975 - is a one-day series of lively discussions that facilitate the exchange of ideas and data. There are no slides or overheads, and all shared data are considered confidential. Postdoctoral research fellows and graduate students are particularly encouraged to attend. It is open to all scientists interested in iron metabolism.

For more info visit:

International BioIron Meeting – 2015


September 6-10, 2015

toh1The International BioIron Society (IBIS) is the premier world organization for researchers and clinicians interested in iron metabolism. BioIron meetings are held every two years at different locations around the world and generally attract more than 300 attendees.

For more info visit:


Future Students

The Knutson lab is currently seeking applications for PhD students to study molecular aspects of iron metabolism.  Competitive applicants will have a strong academic record (in nutrition, biochemistry, chemistry, biology or related discipline), high GRE scores, and strong letters of recommendation.  A master’s degree and/or research experience, especially with biochemistry and molecular biology, is preferred.  If interested, please send brief cover letter (in body of email), resume, and GRE scores to Dr. Knutson at:

ILSI Future Leader

Dr. Knutson with Students

The Food Science and Human Nutrition department is honored to announce that Mitchell Knutson, Ph.D. has been named a 2009 ILSI North America Future Leader in Nutritional Sciences. This is one of the most important accomplishments a nutritional scientist can achieve in the early stages of their career. Dr. Knutson received the award, in part for his outstanding research accomplishments related to the study of iron transport.  Additionally, Mitch has served the American Society for Nutrition and East Coast Iron Club as committee chairs.

ILSI N.A. is a nonprofit, scientific research and educational organization established to advance the understanding of scientific issues relating to nutrition and food safety by bringing together scientists from academia, government, industry, and the public sector to solve problems with broad implications for the well-being of the general public.  ILSI N.A.’s programs are financially supported primarily by its industry membership.

The ILSI NA Future Leader Award, given to promising nutrition and food scientists, allows new investigators the opportunity to add to an existing project or to conduct exploratory research that might not receive funding from other sources or add to an existing project.   The UF FSHN department has one of the largest cohorts of former ILSI Future Leaders including Drs. Cousins,Gregory, BorumPercivalShay, and Henken.